Thursday, February 21, 2008

Treating Epilepsy in Adults with Low Carb

We have all been reminded in the press lately about the benefits of a ketogenic diet in the treatment of children with epilepsy.

Well today I just spotted this new abstract for a study on treating Adults with Epilepsy with a modified Atkins diet, which I thought was good to see as you never see it recommended for adults. I thought I'd share here, as I add it to my low carb research page :)

A Prospective Study of the Modified Atkins Diet for Intractable Epilepsy in Adults

Eric H. Kossoff, Hannah Rowley, Saurabh R. Sinha, and Eileen P. G. Vining


Purpose: The ketogenic diet is not typically offered to adults with epilepsy due to the significant lifestyle alterations needed for its use. The modified Atkins diet has been recently demonstrated to be therapeutic for children without the need for an admission, fasting period, weighing of foods, or fluid, calorie, and protein restriction.

Methods:
A prospective, open-label study was performed of adults over 18 years of age, having at least weekly seizures and prior use of at least two anticonvulsants. Carbohydrates were initially restricted to 15 g/day, fats were encouraged, and fluids, protein, and calories were allowed ad lib.

Results:
Thirty patients, with age ranging from 18 to 53 years, were enrolled. Using an intent-to-treat analysis, 47% had a >50% seizure reduction after 1 and 3 months on the diet; 33% after 6 months. In those with seizure reduction, the median time to improvement was 2 weeks (range: 1–8 weeks). The mean weight loss was 6.8 kg, p < 0.001. Body-mass index (BMI) decrease correlated with efficacy at 3 months, p = 0.03. Ten subjects (30%) discontinued the diet prior to 3 months. Side effects included increased cholesterol (mean 187 to 201 mg/dL), blood urea nitrogen (BUN; 13 to 16 mg/dL), and urine calcium to creatinine ratio (0.14 to 0.19).

Conclusions: A modified Atkins diet appears to demonstrate preliminary efficacy for adults with intractable epilepsy, especially in those who lost weight. Considering the rapid response in those who improved, but somewhat high discontinuation rate, a 2-month trial period may be adequate to assess for efficacy.

Kossoff et al, A Prospective Study of the Modified Atkins Diet for Intractable Epilepsy in Adults. Epilepsia. 2008 Feb;49(2):316-9.

1 comment:

Sharon said...

Hi,

Epilepsy has gone from an obscure mental illness, to a serious illness recognized by state foundations. This remarkable awareness, is because of the great work organizations, such as yourself, has done. We here, at Disease.com, fully support the cause your organization stands for and we are dedicated to aiding in your mission statement. Disease.com is a website which features disease and infection preventions/treatments. If you could, please list us as a resource or host our social book mark button, it would be much appreciated. Lets dedicate our time to the welfare of the 3 million individuals with epilepsy.
If you need more information please email me back with the subject line as your URL.


Thank You,
Sharon Vegoe