Monday, March 05, 2007

Diabetes 2, sugar, weight gain and drugs...

I was just reading this article on the threat of diabetes that had some pretty alarming numbers:

According to the latest World Health Organization (WHO) estimates, the number of people worldwide with diabetes climbed from 30 million in 1985 to 171 million in 2000.

Some 4 percent to 6 percent of adults aged 20 and over are now affected. Developed nations tend to have a higher prevalence, but developing nations are fast catching up.

There was a 69 percent increase -- from 5.2 percent to 8.8 percent -- in diabetes prevalence from 1995 to 2005, exceeding the WHO's estimate of a 60 percent global increase between 1995 and 2030 and a 39 percent increase between 2000 and 2030.

"Every estimate I have ever seen for prevalence has been surpassed the next time you get a chance to look. It's quite frightening," he said.

Now obviousely (well to us anyway!), our diet has a lot to do with this, particulary where highly refined processed foods are concerned, but I also wonder how many drugs out there that we are put on in the hope of curing our ails are also to blame?

My partner has been having a huge battle of late with major depression. They think now that it is a symptom of something else but they don't know what so they are just throwing drugs at him and seeing if they help basically *rolls eyes:
To date every treatment they have given him has made him worse. His previous medication was clearly causing blood sugar issues as I watched him begin to turn back into a sugar addict and gain weight. His eating didn't get too bad but it was only going to get worse and he wouldn't believe me when I said he was having problems with his blood sugar.

Last week he was changed to another drug (Zyprexa) which I looked up and OMG lots of side effects but the ones that stood out to me were major weight gain, syndrome x, hypoglyceamia and diabetes 2 caused by changes to your glucose metabolism.

I talked Garry into mentioning this to his shrink, in which the shrink seemed to have played it down.

I have been hunting for the research article that I was looking at last week, but I seemed to have lost it but here are a couple of articles for anyone interested.

Olanzapine (Zyprexa) on Wikipedia.

Recently the FDA required the manufacturers of all atypical antipsychotics to include a warning about the risk of hyperglycemia and diabetes with atypical antipsychotics. Additionally there are some case reports of olanzapine-induced diabetic ketoacidosis. There are data showing that olanzapine can decrease insulin sensitivity.[citation needed] In addition, increased triglyceride levels may also be an issue with olanzapine. Impaired glucose metabolism, high triglycerides, and obesity have been shown to be constituents of the metabolic syndrome and may increase the risk of cardiovascular disease.

The Zyprexa story (Transcript should be up by Thursday but you can listen to it now)

Pharmaceutical company Eli Lilly (makers of Prozac) have agreed to pay upwards of 1.2 billion US dollars to nearly 30,000 patients who claim their bestseller antipsychotic medication, Zyprexa (Olanzapine) has resulted in diabetes, weight gain and other complications and that these risks were downplayed. Secret documents are leaked, the newspaper headlines start screaming, and citizen journalists spread the word - but where is the real advocacy for better drugs with fewer side effects?
Zyprexa Documents

I wonder just how many drugs out there have these types of side effects?

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